Work

Catalysis in the Service of Green Chemistry: Nobel Prize-Winning Palladium-Catalysed Cross-Couplings, Run in Water at Room Temperature

Year: 2012

Type: article

Abstract: Palladium-catalysed cross-couplings, in particular Heck, Suzuki-Miyaura and Negishi reactions developed over three decades ago, are routinely carried out in organic solvents. However, alternative media are currently of considerable interest given an increasing emphasis on making organic processes 'greener'; for example, by minimising organic waste in the form of organic solvents. Water is the obvious leading candidate in this regard. Hence, this review focuses on the application of micellar catalysis, in which a 'designer' surfactant enables these award-winning coupling reactions to be run in water at room temperature.

Source: Platinum Metals Review

DOI: 10.1595/147106712x629761

Authors: Bruce H. Lipshutz, Benjamin R. Taft, Alexander R. Abela, Subir Ghorai, Arkady Krasovskiy, Christophe Duplais