A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk
Year: 2016
Type: review
Abstract: The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (Ptrend all ≤ 0.005), and IGFBP-1 was inversely associated weakly with risk (Ptrend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (Pheterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, Pheterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development. Cancer Res; 76(8); 2288-300. ©2016 AACR.
Source: Cancer Research
Authors: Ruth C. Travis, Paul N. Appleby, Richard M. Martin, Jeff M.P. Holly, Demetrius Albanes, Amanda Black, H. Bas Bueno-de-Mesquita, June M. Chan, Chu Chen, Maria-Dolores Chirlaque, Michael B. Cook, Mélanie Deschasaux, Jenny L. Donovan, Luigi Ferrucci, Pilar Galan, Graham G. Giles, Edward L. Giovannucci, Marc J. Gunter, Laurel A. Habel, Freddie C. Hamdy, Kathy J. Helzlsouer, Serge Hercberg, Robert N. Hoover, Joseph A.M.J.L. Janssen, Rudolf Kaaks, Tatsuhiko Kubo, Loic Le Marchand, E. Jeffrey Metter, Kazuya Mikami, Joan K. Morris, David E. Neal, Marian L. Neuhouser, Kotaro Ozasa, Domenico Palli, Elizabeth A. Platz, Michael N. Pollak, Alison J. Price, Monique J. Roobol, Catherine Schaefer, Jeannette M. Schenk, Gianluca Severi, Meir J. Stampfer, Pär Stattin, Akiko Tamakoshi, Catherine M. Tangen, Mathilde Touvier, Nicholas J. Wald, Noel S. Weiss, Regina G. Ziegler, Timothy J. Key, Naomi E. Allen
Institutions: University of Oxford, University of Bristol, MRC Integrative Epidemiology Unit, National Cancer Institute, Division of Cancer Epidemiology and Genetics, University Medical Center Utrecht, University of Malaya, National Institute for Public Health and the Environment, Imperial College London, University of California, San Francisco, Fred Hutch Cancer Center, Instituto Murciano de Investigación Biosanitaria, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Inserm, Université Sorbonne Paris Nord, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre de Recherche Épidémiologie et Statistique, National Institute on Aging, The University of Melbourne, Cancer Council Victoria, Harvard University, Kaiser Permanente, Kaiser Permanente Northern California, Mercy Medical Center, Mercy Medical Center, Erasmus MC, German Cancer Research Center, University of Occupational and Environmental Health Japan, University of Hawaii Cancer Center, University of Tennessee Health Science Center, Kyoto Prefectural University of Medicine, Queen Mary University of London, University of Cambridge, Radiation Effects Research Foundation, Johns Hopkins University, McGill University, University of Washington, Italian institute for Genomic Medicine, Brigham and Women's Hospital, Uppsala University Hospital, Umeå University, Hokkaido University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Estimated APC paid: $2,853
Awards: G1023702118, G125972088, G1327305488, G153510172, G1548097448, G1632577609, G2271985195, G247538147, G2548880556, G270907595, G2800149121, NIHR Senior Investigator Award, PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research, G3220743633, G34347772, G3785209656, G3982008275, G4015216323, G423252844, G4450071017, G4529913960, G5479317095, G557084418, CHS Events Follow-up Study, G6682065591, G6687401033, G6723261869, G6738037982, G675132270, G6820515600, G752811698, Molecular Epidemiology of Nutrition and Cancer in the Multiethnic Cohort Study, G9000087509, G9000216934, G905887895
OpenAlex ID: W2274299408