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Synthesis and purification of oligodeoxyribonucleotides: a modified approach

Year: 1987

Type: article

Abstract: A reduction in monomer consumption in the solid phase synthesis of oligodeoxyribonucleotides has been achieved by introducing a repeat coupling approach. Additionally, a method of anion exchange HPLC- purification of the synthesized nucleotides at room temperature has been developed in which a highly volatile buffer was used as the eluent. An alternative approach of HPLC purification of oligonucleotides is also reported.

Source: NOT FOUND REPOSITORY (Indian Institute of Science Bangalore)

Authors: Kumud Majumder, Latha P Kadalayil, SK Brahmachari

Language: English

Topic: DNA and Nucleic Acid Chemistry

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funder: Universität Ulm

OpenAlex ID: W2275422012

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