Year: 1994
Type: article
Abstract: studies on calmodulin have indicated that significant conformational changes occur in the secondary structure upon binding of Ca(II).This paper will report our findings concerning possible competitive Al(III) binding to calcium-bound calmodulin.FTIR spectra of the characteristic Amide I region have been analyzed by curve-fitting, difference, second-derivative and deconvolution methods.In addition, techniques to compensate for high absorption peaks due to atmospheric water have been utilized.Our results indicate a large degree of shifting in α-helical and ß-sheet structures upon initial addition of Al(III) with subsequent changes occurring upon further ion binding.
Source: Main Group Metal Chemistry
Authors: William J. Royea,, Ralph L. Amey,
Institution: Occidental College
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $1,187
OpenAlex ID: W2277415172