Work

Multiple fixed drug eruption caused by ropinirole in a patient with Parkinson's disease

Year: 2016

Type: article

Abstract: Parkinson's disease is derived from a degeneration of the dopaminergic neurons in the substantia nigra pars compacta, which leads to a marked loss of striatal dopamine concentration. Among the treatment for Parkinson's disease, the number of patients taking dopamine D2 receptor agonist is on the rise. Ropinirole, a selective dopamine D2 receptor agonist, shows a strong inhibitory effect on the pathogenesis of Parkinson's disease. 1 Although several adverse events of ropinirole are well-known, such as sleep disturbance, a drug eruption due to ropinirole has not been reported in English so far. Herein, we describe here an unusual case of a patient with Parkinson's disease who developed multiple fixed drug eruption after ropinirole treatment. We also reviewed the past literature on drug eruption caused by other dopamine D2 receptor agonists further. A 60-year-old female with Parkinson's disease was referred to our department for evaluation of an eruption of 2 days' duration. An erythematous eruption on the extremities had developed three hours after 7th daily administration of ropinirole for her Parkinson's disease. The erythematous lesions gradually became pigmented. On physical examination, well-defined pigmentations

Source: Allergology International

DOI: 10.1016/j.alit.2015.12.003