Work

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

Year: 2016

Type: review

Abstract: The aim of this review is to provide an update on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases. The cyclic structure of cyclodextrins and their toroidal shape are perfectly suitable to design new chemical scavengers able to trap and hydrolyze the organophosphorus compounds before they reach their biological target.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.12.23

Authors: Sophie Letort, Sébastien Balieu, William Erb, Géraldine Gouhier, François Estour

Institutions: Centre National de la Recherche Scientifique, Normandie Université, Laboratoire COBRA, Université de Rouen Normandie, Institut National des Sciences Appliquées Rouen Normandie

Language: English

Topic: Supramolecular Chemistry and Complexes

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: Indian National Science Academy, Agence Nationale de la Recherche, Centre National de la Recherche Scientifique, Région Normandie