Work

Control of ornithine decarboxylase activity in stimulated human lymphocytes by putrescine and spermidine

Year: 1973

Type: article

Abstract: Ornithine decarboxylase activity in extracts of phytohaemagglutinin-stimulated human lymphocytes is rapidly and extensively inhibited by additions of micromolar concentrations of putrescine or spermidine to the culture medium. This inhibition is not due to feedback inhibition of the enzyme by putrescine, spermidine or their metabolites. Inhibition is dependent on the continuation of protein synthesis, but does not require RNA synthesis. The effect of putrescine is abolished when its conversion into spermidine by the cells is prevented.

Source: Biochemical Journal

DOI: 10.1042/bj1320791

Authors: John E. Kay, Valerie J. Lindsay

Institution: University of Sussex

Language: English

Topic: Polyamine Metabolism and Applications

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funder: Medical Research Council

OpenAlex ID: W2290489752