Year: 2013
Type: dissertation
Abstract: The main objective of this thesis is to understand the mechanism of endothelial behaviors during network formation process, the initial step of angiogenesis, in a fluidic multilayered myoblast sheet, through the construction of a novel 3D in vitro culture system which imitates the in vivo angiogenesis using cell sheet engineering.The effects of various factors, such as the thickness of the cell sheet, the culture time, and the density of endothelial cells on network formation process are discussed.The author hopes that the findings in this work will offer a deeper understanding of cell behaviors in 3D structures and open the way to future application in regenerative medicine.
DOI: 10.18910/26216
Author: Trung Xuan Ngo
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: green
OpenAlex ID: W2290650702