Year: 2016
Type: article
Abstract: We present a wide-field quantitative label-free imaging of mouse brain tissue slices with sub-micrometre resolution, employing holographic microscopy and an automated scanning platform. From the measured light field images, scattering coefficients and anisotropies are quantitatively retrieved by using the modified the scattering-phase theorem, which enables access to structural information about brain tissues. As a proof of principle, we demonstrate that these scattering parameters enable us to quantitatively address structural alteration in the brain tissues of mice with Alzheimer's disease.
Source: Scientific Reports
DOI: 10.1038/srep31034
Authors: Moosung Lee, Eeksung Lee, JaeHwang Jung, Hyeonseung Yu, Kyoohyun Kim, Jonghee Yoon, Shinhwa Lee, Yong Jeong, YongKeun Park
Institution: Korea Advanced Institute of Science and Technology
Language: English
Subfield: Atomic and Molecular Physics, and Optics
Field: Physics and Astronomy
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W2291553696