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Therapeutic implication of molecular profiling in patients with non – small cell lung cancer

Year: 2012

Type: article

Abstract: Traditional, 'one size fits all' approach to chemotherapy has reached efficacy plateau.The development of molecular biomarkers is crucial for improving efficacy of therapy in patients with NSCLC.We review prognostic and predictive value of molecular biomarkers with special overview on biomarker-driven personalized therapy of NSCLC.Main focus is this review is on significance of EGFR mutations and ALK -EML4 alterations on due to availability of targeted drugs against these specific aberrations.

Source: Hrčak Portal of scientific journals of Croatia (University Computing Centre)

Authors: Marko Jakopović, Silvana Smojver Ježek, Nabil Chalfe, Gzim Redžepi, Mateja Janković, Branka Čučević, Dina Mihelčić, Dinko Stančić Rokotov, Miroslav Samaržija

Institutions: University Hospital Centre Zagreb, University of Zagreb

Language: English

Topic: Lung Cancer Treatments and Mutations

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2291652247

FWCI:

Cites: 70

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Related to: 10