Year: 2016
Type: article
Study design: Observational Study
Abstract: // Li-Xin Qiu 1, 2, * , Rui-Xi Hua 3, * , Lei Cheng 2, * , Jing He 4 , Meng-Yun Wang 2 , Fei Zhou 2 , Xiao-Dong Zhu 1 , Meng-Hong Sun 5 , Xiao-Yan Zhou 5 , Jin Li 1 , Ya-Nong Wang 6 , Ya-Jun Yang 7, 8 , Jiu-Cun Wang 7, 8 , Li Jin 7, 8 , Wei-Jian Guo 1 , Qing-Yi Wei 2, 9 1 Department of Medical Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 2 Cancer Institute, Collaborative Innovation Center for Cancer Medicine, Fudan University Shanghai Cancer Center, Shanghai, China 3 Department of Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China 4 Department of Pediatric Surgery, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China 5 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China 6 Department of Gastric Cancer and Soft Tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai, China 7 Ministry of Education Key Laboratory of Contemporary Anthropology and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China 8 Fudan-Taizhou Institute of Health Sciences, Taizhou, Jiangsu, China 9 Duke Cancer Institute, Duke University Medical Center and Department of Medicine, Duke University School of Medicine, Durham, NC, USA * These authors contributed equally to this work Correspondence to: Wei-Jian Guo, e-mail: [email protected] Qing-Yi Wei, e-mail: [email protected] and [email protected] Keywords: gastric cancer, genetic susceptibility, MUC1, polymorphism Received: November 22, 2015 Accepted: February 09, 2016 Published: February 20, 2016 ABSTRACT Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31–0.73; AG/GG vs. AA, OR = 0.82, 95% CI = 0.68–0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32–0.74]. These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta-analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.
Source: Oncotarget
Institutions: Shanghai Medical College of Fudan University, Fudan University, Fudan University Shanghai Cancer Center, Shanghai Cancer Institute, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou Women and Children Medical Center, Guangzhou Medical University, State Key Laboratory of Genetic Engineering, Duke University, Duke Medical Center, Duke Cancer Institute
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2294586972