Work

Protective effects of Withania somnifera root on inflammatory markers and insulin resistance in fructose-fed rats.

Year: 2015

Type: article

Abstract: BACKGROUND: We investigated the effects of Withania somnifera root (WS) on insulin resistance, tumor necrosis factor α (TNF-α), and interleukin-6 (IL-6) in fructose-fed rats. METHODS: Forty-eight Wistar-Albino male rats were randomly divided into four groups (n=12); Group I as control, Group II as sham-treated with WS by 62.5mg/g per diet, Group III fructose-fed rats received 10%W/V fructose, and Group IV fructose- and WS-fed rats. After eight weeks blood samples were collected to measure glucose, insulin, IL-6, and TNF-α levels in sera. RESULTS: Blood glucose, insulin, homeostasis model assessment for insulin resistance (HOMA-R), IL-6, and TNF-α levels were all significantly greater in the fructose-fed rats than in the controls. Treatment with WS significantly (P < 0.05) inhibited the fructose-induced increases in glucose, insulin, HOMA-R, IL-6, and TNF-α. CONCLUSION: Our data suggest that WS normalizes hyperglycemia in fructose-fed rats by reducing inflammatory markers and improving insulin sensitivity.

Source: Europe PMC (PubMed Central)

Authors: Zahra Samadi Noshahr, Mohammad Reza Shahraki, Hassan Ahmadvand, Davood Nourabadi, Alireza Nakhaei

Institutions: Zahedan University of Medical Sciences, Lorestan University of Medical Sciences, Iran University of Medical Sciences

Language: English

Topic: Phytochemicals and Medicinal Plants

Subfield: Complementary and alternative medicine

Field: Medicine

Domain: Health Sciences

SDGs: Good health and well-being, Zero hunger

Open Access status: green

OpenAlex ID: W2297669366

FWCI: 2.473

Cites: 22

Cited by: 24

Related to: 10