Die Rolle der Bone-Morphogenetic-Proteine (BMP) -2 und -5 in der adulten humanen Niere und bei der hypertensiven Nephrosklerose
Year: 2015
Type: dissertation
Abstract: Bone Morphogentic Proteins (BMP) have extensive functions in the embryogenesis and organogenesis as well as in tissue regeneration of the adult organism. BMP-7 possesses protective and regenerative capabilities in the human adult kidney. The closely related BMP-5 is involved in the nephrogenesis as well, but its role regarding the adult kidney is not well determined yet. BMP-2 ist crucial in the embryogenesis. It induces differentation, migration and proliferation of embryonic stem cells and is essential in the osteogenesis. The role of BMP-2 in the human adult kidney is unknown. The aim of this study was to examine the expression, function and regulation of BMP-2 and BMP-5 in the human adult kidney, hypertensive nephrosclerosis and in diverse renal cell lines.
Author: Bevanda, Jelena
Institution: University of Göttingen
Language: German
Topic: TGF-β signaling in diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2297880909