Year: 2012
Type: article
Abstract: Sum maryObjective: Hyperthermia may induce pathologic alterations within body systems and organs including brain.In this study, neuronal effects of endogenous and exogenous hyperthermia (41 °C) were studied in rats. Ma te ri al and Met hod:The endogenous hyperthermia (41 °C) was induced by lipopolysaccharide and the exogenous by an (electric) heater.Possible neuronal damage was evaluated by examining healthy, apoptotic and necrotic cells, and heat shock proteins (HSP 27, HSP 70) in the cerebral cortex, cerebellum and hypothalamus.Re sults: At cellular level, when all neuronal tissues are taken into account; (i) a significant increase in the necrotic cells was observed in the both groups (p<0.05),(ii) while exogenous hyperthermia did not affect apoptotic process significantly, endogenous hyperthermia led to a significant increase in apoptosis (p<0.05),whereas (iii) HSP 70 levels increased in neuronal tissues (p<0.05) in the endogenous hyperthermia group, but they decreased in the exogenous hyperthermia group (p<0.05).No statistically significant change was observed in HSP 27 levels in both of the groups (p>0.05). Dis cus si on:The neural tissue of brain can show different degree of response to hyperthermia.But we can conclude that endogenous hyperthermia is more harmful to central nervous system than exogenous hyperthermia.(
Source: Turkish Journal Of Neurology
DOI: 10.4274/tnd.53244
Authors: Mustafa Aydın, Fatih Mehmet Kışlal, Mustafa Demirol, Feyza İnceköy Girgin, Nimet Kabakuş, Mesut Koçak
Institutions: Fırat University, S.B. Keçiören Eğitim ve Araştırma Hastanesi
Language: Turkish
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2316004282