Evaluation of Protective Effect of Vitamin -e on Vincristine Induced Peripheral Neuropathy in Albino Rats
Year: 2013
Type: article
Abstract: BACK GROUND:Vitamin -E is a lipid soluble substance which ,effectively protects against neuronal toxicity by preventing free -radical damage to biological membrane.It is a major antioxidant used clinically and its study in nerve injury models has not been encountered in literature.METHODS :In the present study ,the neuroprotective effect of vitamin-E ( graded doses of 50mg/kg,100mg/kg,200mg/kg orally) were assessed by giving vitamin -E daily for 14 days followed by vincristine(100 µg/kg I.P) on alternative days for 14 days in albino rats to induce peripheral neuropathy.The protective effect of vitamin-E were assessed by analgesic models like tail flick method, tail immersion methods and tail clip method on 0,7 & 14th day. RESULTS AND CONCLUSION :vitamin -E treated groups with 100mg/kg and 200mg/kg showed significant reduction in reaction time on 7th and 14th day compared to control group in all the three models of experiments.These findings indicate that vitamin-E has a promising neuroprotective action in treating hyperalgesia in models of rats.
DOI: 10.14260/jemds/574
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2319985652