Year: 2007
Type: article
Abstract: The dichloromethane extract of Calea uniflora afforded a mixture of two novel chromanones, uniflorol-A (1) and uniflorol-B (2), and one known chromanone, 2,2-dimethyl-6-(1-hydroxyethyl)-chroman-4-one (3). The structures of these compounds were determined by spectroscopic methods. Biological activity of the compounds against Leishmania major promastigotes was evaluated. Mixture of the novel chromanones 1 and 2 showed significant growth inhibition of the parasite in the micrograms per milliliter range.
Source: Zeitschrift für Naturforschung C
Institutions: Universidade de São Paulo, Instituto de Física de São Carlos
Language: English
Topic: Bioactive natural compounds
Subfield: Drug Discovery
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $2,712
OpenAlex ID: W2320152737