Work

Cefodizime, an aminothiazolylcephalosporin. V. Synthesis and structure-activity relationships in the cefodizime series.

Year: 1987

Type: article

Abstract: The synthesis as well as in vitro antibacterial activity and pharmacokinetic behavior of cefodizime (HR 221, 1a), its analogs and derivatives is described. In this comparison, cefodizime stands out for its balance between its high antibacterial activity, prolonged elimination half-life and high AUC in mice and dogs.

Source: The Journal of Antibiotics

DOI: 10.7164/antibiotics.40.29

Authors: JÜRGEN BLUMBACH, WALTER DÜRCKHEIMER, EBERHARD EHLERS, KLAUS FLEISCHMANN, NORBERT KLESEL, MICHAEL LIMBERT, BURKHARD MENCKE, JÜRGEN REDEN, KARL H. SCHEUNEMANN, ELMAR SCHRINNER, GERHARD SEIBERT, MANFRED WIEDUWILT, MANFRED WORM

Language: English

Topic: Synthesis of β-Lactam Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2321055873

FWCI: 3.215

Cites: 8

Cited by: 20

Related to: 10