Work

Solution Structure of HIV-1 Protease-Allophenylnorstatine Derivative Inhibitor Complex Obtained from Molecular Dynamics Simulation.

Year: 1994

Type: article

Abstract: Structures of two enzyme-inhibitor complexes of human immunodeficiency virus-1 protease with allophenylnorstatine derivatives were obtained from molecular dynamics simulation in aqueous solution. The stronger inhibitor gave considerably smaller fluctuation at P3 site, which formed hydrogen bonding with the enzyme flap region.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.42.176

Authors: Ryohei KATO, Osamu TAKAHASHI, Yoshiaki KISO, Ikuo MORIGUCHI, Shuichi HIRONO

Institution: Kitasato University

Language: English

Topic: Protein Structure and Dynamics

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2323360415

FWCI: 0.212

Cites:

Cited by: 14

Related to: 10