Work

Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design

Year: 2016

Type: review

Abstract: Traditionally, vaccines have been developed by cultivating infectious agents and isolating the inactivated whole pathogen or some of its purified components. 20 years ago, reverse vaccinology enabled vaccine discovery and design based on information deriving from the sequence of microbial genomes rather than via the growth of pathogens. Today, the high throughput discovery of protective human antibodies, sequencing of the B cell repertoire, and the increasing structural characterization of protective antigens and epitopes provide the molecular and mechanistic understanding to drive the discovery of novel vaccines that were previously impossible. We are entering a "reverse vaccinology 2.0" era.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.20151960

Authors: Rino Rappuoli, Matthew J. Bottomley, Ugo D’Oro, Oretta Finco, Ennio De Gregorio

Language: English

Topic: vaccines and immunoinformatics approaches

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Seventh Framework Programme

Award: G3954954852