Work

The Need for Speed in Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry

Year: 2016

Type: article

Abstract: Imaging mass spectrometry (IMS) has emerged as a powerful analytical tool enabling the direct molecular mapping of many types of tissue. Specifically, matrix-assisted laser desorption/ ionization (MALDI) represents one of the most broadly applicable IMS technologies. In recent years, advances in solid state laser technology, mass spectrometry instrumentation, computer technology, and experimental methodology have produced IMS systems capable of unprecedented data acquisition speeds (>50 pixels/second). In applications of this technology, throughput is an important consideration when designing an IMS experiment. As IMS becomes more widely adopted, continual improvements in experimental setups will be important to address biologically and clinically relevant time scales.

Source: Postdoc Journal

DOI: 10.14304/surya.jpr.v4n3.1

Authors: Boone M. Prentice, Richard M. Caprioli

Institution: Vanderbilt University

Language: English

Topic: Mass Spectrometry Techniques and Applications

Subfield: Spectroscopy

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: Molecular Profiling of Pancreatic Pathophysiology by Imaging Mass Spectrometry, Imaging Mass Spectrometry Research Resource at Vanderbilt University