Work

Asymmetric Total Synthesis of (+)-Virosine A via Sequential Nucleophilic Cyclizations onto an Activated Formamide

Year: 2012

Type: article

Abstract: The first synthesis of tetracyclic alkaloid virosine A is reported. The natural alkaloid was prepared in only 13 steps, in an enantioenriched form. The azabicyclo[2.2.2]octane core was efficiently assembled using a key Vilsmeier-Haack and Mannich cyclizations sequence performed in one pot.

Source: The Journal of Organic Chemistry

DOI: 10.1021/jo202651t

Authors: Guillaume Bélanger, Marianne Dupuis, Robin Larouche-Gauthier

Institution: Université de Sherbrooke

Language: English

Topic: Advanced Synthetic Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: Natural Sciences and Engineering Research Council of Canada

OpenAlex ID: W2324536749

FWCI: 1.914

Cites: 21

Cited by: 36

Related to: 10