Year: 1988
Type: article
Study design: Observational Study
Abstract: The plasma levels of von Willebrand factor (vWF), factor VIII procoagulant activity (factor VIII) and protin C (PC), were followed in 39 patients with myocardial infarction (MI).The mean vWF activity in the acute stage of MI was significantly higher (p<0.01) than that in age-matched controls, whereas in the chonic stage there was no statistically significant difference (Fig. 1).Factor VIII was not significantly higher than in controls at any stage.The vWF activities in patients with acute myocardial infarction were not correlated at all with peak CPK levels (Fig. 2).The mean PC values in MI patients were normal, but 17 patients with abnormally high vWF activity in the acut stage showed PC values significantly lower than those of both nomal controls and 8 patients with nomal vWF activity.It appeared that increased plasma vWF activity was possibly associated with an increased risk of death from acute myocardial infarction.The low PC antigen level in patients with higher vWF activity was perhaps due to PC consumption in the acute stage of this disease.The mechanism of this disease in patients with nomal vWF activity at onset is probably due to spasm of the coronary artery.
Source: Blood & Vessel
Institutions: Kure Medical Center, Hiroshima University
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2329385482