In Vivo Assesment of Anti-trypanasomal Effect of Rosemary (Rosmarinus officinalis) In Rabbits
Year: 2014
Type: article
Abstract: Today, tropical diseases pose significant risk to animal and human populations worldwide.Most of which were classified as neglected tropical diseases, having an enormous impact on socio-economic development and quality of life at all levels particularly in developing countries.At present, a lot of research is committed to sleeping sickness, not only because they are major killing diseases but also because disease control becomes more difficult due to a number of factors that limit the utility of current drugs in resource-poor settings, such as high cost, poor compliance, drug resistance, low efficacy and poor safety.Hence, the search for new and preferably cheap drugs needs to be continued.Natural products are still major potential sources of innovative therapeutic agents for various conditions, including infectious diseases as they represent an unmet source of chemical diversity.This study was conducted in order to determine the anti-trypanosomal properties of crude chloroform extract (CCE) of Rosmarinus officinalis.A total of thirty rabbits (n=30) of about 5 -6 months old, weighing 1.5 -2.5 kg were enrolled and divided into six main groups of five animals each.The course of Trypanosoma evansi infection in rabbits was followed for 48 days post-infection.Animals were closely observed for clinical examination.Blood samples were taken to measure haematological and biochemical parameters.Our results revealed abnormalities in all investigated parameters in infected group.In contrast, animals treated with CCE of Rosmarinus officinalis showed normalization in their haematological and biochemical values thereby confirming their anti-parasitic properties.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2329508151