Work

Antitumor activity of 2-acylamino-1,3,4-thiadiazoles and related compounds.

Year: 1982

Type: article

Abstract: 2-Nitrosoureido-1, 3, 4-thiadiazoles were effective against both mouse lymphoid leukemia L1210 and rat ascites hepatoma AH13. Some 2-acylamino-1, 3, 4-thiadiazoles were also effective against L1210. The anti-L1210 action of these 2-acylamino-1, 3, 4-thiadiazoles was blocked by administration of nicotinamide. Among these compounds, 2-propanoylamino-1, 3, 4-thiadiazole was the most effective against L1210, with a maximum T/C% of 166.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.30.4402

Authors: MICHIKO MIYAHARA, MASAHIRO NAKADATE, SHOKO SUEYOSHI, MASAYUKI TANNO, MAKOTO MIYAHARA, SHOZO KAMIYA

Institution: National Institute of Health Sciences

Language: English

Topic: Structural and Chemical Analysis of Organic and Inorganic Compounds

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2329612973