Extensive squamous metaplasia in the rectum stained with a Lugol’s solution in patient with ulcerative colitis and primary sclerosing cholangitis
Year: 2014
Type: article
Study design: Case Report
Abstract: A case of extensive squamous metaplasia in a patient with longstanding ulcerative colitis and primary sclerosing cholangitis is presented. The patient was a 52-year-old man with a 20-year history of pancolitis who was referred for surveillance colonoscopy. No suspicious lesions had been found on previous examinations. Inspection of the rectum revealed a whitish epithelium lining the distal portion of the bowel, which was almost complete in circumferential extent and approximately 2 cm long at its maximum extent ([ Fig. 1 ]). Lugol’s solution, known for its interaction with glycogen in a squamous epithelium, was used as a stain. An irregular border between the rectal mucosa and the metaplastic epithelium was clearly demarcated, and details of the surface of the latter could be easily observed ([ Fig. 2 ]). As expected, histopathology confirmed the presence of squamous epithelium in the rectum. Fig. 1 A whitish epithelium in the distal rectum adjacent to the inflamed rectal mucosa. Fig. 2 The rectal mucosa and the squamous metaplasia stained with Lugol’s solution. Although extremely rare, squamous metaplasia and squamous carcinoma of the rectum have been observed in longstanding ulcerative colitis [ 1 ] [ 2 ] [ 3 ]. In addition to chronic inflammation, human papilloma virus infection may play a role in the metaplasia – dysplasia – carcinoma sequence [ 1 ]. To the best of our knowledge, the combination of ulcerative colitis, squamous metaplasia, and primary sclerosing cholangitis has not been previously described. Endoscopy_UCTN_Code_CCL_1AD_2AD
Source: Endoscopy
Language: English
Topic: Inflammatory Bowel Disease
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2329799795