Year: 1998
Type: article
Study design: Observational Study
Abstract: We evaluated the clinical data in 83 patients with sepsis, which was diagnosed by both Bone's definition of sepsis and positive isolates from blood culture, according to their underlying diseases. This study enrolled a total of 117 septic episodes in 83 patients (57 males and 26 females, mean age: 52.0 years). We classified 3 groups, including hematological malignancies (46 patients, 72 episodes), solid malignant tumors (23 patients, 25 episodes) and non-malignancies (14 patients, 20 episodes), by the underlying diseases. Of the total number of isolates from blood culture, 53.0% were single gram-positive bacteria, 33.3% were single gram-negative bacteria, 7.7% were single fungus and 6.0% were polymicrobial organisms. In addition, coagulase negative staphylococci was isolated most often in patients with hematological malignancies. Sepsis was often caused by infectious focuses of hemorrhoid, stomatitis or intravenous catheter in patients with hematological malignancies, by pneumonia in patients with solid malignant tumors and by urinary tract infection in patients with non-malignancies. Mortality of sepsis in patients with solid malignant tumors (48%) was highest in 3 groups. Septic patients, who were complicated with shock and/or DIC, has poor prognosis in all groups. Serum albumin level was significantly lower in dead patients than patients who survived. These results suggest that clinical features may be different according to the underlying diseases of patients with sepsis.
Source: Kansenshogaku zasshi
Authors: Mitsuru KONISHI, Kei MORI, Toshimasa MAJIMA, Katsuhiro UEDA, Shoji TERAMOTO, Masahiro SAKAMOTO, Masayuki TSUJIMOTO, Koichi MAEDA, Keiichi MIKASA, Masayoshi SAWAKI, Akira KOIZUMI, Reiko SANO, Takayuki MASUTANI, Nobuhiro NARITA
Institution: Nara Medical University
Language: Japanese
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2330601397