Significance of Serum Gamma Glutamyl Transferase in Gastro - Intestinal and Hepato Biliary Pancreatic Mal I Gnancies With Specific Consideration to Hepatic Metastasis
Year: 2014
Type: article
Study design: Observational Study
Abstract: In this study forty patient's suffering from various gastro intestinal, hepato biliary and pancreatic malignancies specific of serum GGT is studied in patients with hepatic metastasis and also in patients with primary hepatocellular carcinoma along with 20 healthy control.Prospective qualitative study was performed with groups divided based on with or without hepatic metastasis keeping HCC on other end and also into pre and post intervention groups.The result obtained from our study indicates a significant increase of GGT in serum level in patients of HCC.Apart from this, patients suffering from cholangio carcinoma stage IV were also found to be having raised serum GGT level.On the other hand in ca stomach, ca rectum and ca anal canal did not show raised serum Y-GT level but it was raised to some extent in cholangio carcinoma and ca gall bladder cancer particularly in advanced stages like stage III and IV and also even without other evidence, marker's of hepatic metastasis.These observations showed that raised GGT gives a clear indication for involvement of liver in advanced stage of cancer.Also as per literature and results is in accordance to our study hence serum GGT levels can be well utilized for prognostic purpose before secondary spread into the liver and also very good tool for metastatic detection and recurrence and for follow up in combination with other markers specific to hepatic parenchyma involvement.
Language: English
Subfield: Hepatology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2330757706