Year: 2014
Type: article
Study design: Observational Study
Abstract: INTRODUCTION: Hypertension is one of the risk factors for cardiovascular disease and causes progressive damage to kidney in a long term process.Hypertension impairs glomerular function and also leads to subclinical atherogenesis, there is a excretion of low molecular weight compounds like albumin and amylase in urine.This study was conducted to analyze the changes in amylase levels in hypertension.MATERIAL AND METHODS: This is a hospital based study.The patients attending the medicine department were selected for the study.60 subjects were selected based on history and clinical examination consisting of 30 hypertensive patients and 30 normotensive subjects in the age group 35-60 years.Blood samples collected in vacutainers were analyzed in the clinical biochemistry laboratory.Serum samples were analyzed for total protein, albumin and amylase.RESULT: The study showed a statistically significant change in the levels of serum albumin and amylase.The level of serum albumin was 3.71 ± 0.22 g/dl in cases while it was 4.14 ± 0.20 g/dl in controls.The serum amylase levels were 99.79 ±13.63 U/L in cases while it was 137.76 ± 16.86 U/L in the control.The p-value was 0.0001 which was statistically significant. CONCLUSION:The initial damage to glomerulus can be detected by the alteration in serum amylase values in hypertension.Thus serum amylase can be considered as an early marker for detecting the renal damage in hypertension.
Authors: Rangaswamy R, Swathi K
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2331348024