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Mp07-12 Abdominal Obesity, Altered Adipokynes and Elevated C-peptide Levels Are Associated With High Gleason Score in Patients Undergoing Diagnostic Prostate Biopsy: Data From Prospective Registry

Year: 2016

Type: article

Abstract: You have accessJournal of UrologyProstate Cancer: Markers II1 Apr 2016MP07-12 ABDOMINAL OBESITY, ALTERED ADIPOKYNES AND ELEVATED C-PEPTIDE LEVELS ARE ASSOCIATED WITH HIGH GLEASON SCORE IN PATIENTS UNDERGOING DIAGNOSTIC PROSTATE BIOPSY: DATA FROM PROSPECTIVE REGISTRY Jehonathan H. Pinthus, Katie M. Di Sebastiano, Wilhelmina C.M. Duivenvoorden, Joel A. Dubin, and Marina Mourtzakis Jehonathan H. PinthusJehonathan H. Pinthus More articles by this author , Katie M. Di SebastianoKatie M. Di Sebastiano More articles by this author , Wilhelmina C.M. DuivenvoordenWilhelmina C.M. Duivenvoorden More articles by this author , Joel A. DubinJoel A. Dubin More articles by this author , and Marina MourtzakisMarina Mourtzakis More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2215AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The development of prostate cancer (PC) has been associated with numerous lifestyle factors (obesity, physical activity, nutrition) and metabolic perturbations. We aimed to prospectively characterize an integrative metabolic profile of men undergoing diagnostic prostate biopsies. METHODS We prospectively evaluated 51 consecutive men for body composition, metabolic syndrome, glucose- and lipid-related measures and lifestyle factors including physical function and nutritional intake prior to prostate biopsy. These factors were related to the Gleason score obtained from the extended (16-26 cores) transrectal ultrasound guided biopsy performed for prostate cancer diagnosis. one-way Analysis of Variance (ANOVA) and linear regression were used. RESULTS Mean age and BMI of the participants were 66 years with and 28.2 kg/m2. Metabolic syndrome was identified in 32 of 51 (63%) participants based on criteria from the International Diabetes Federation. Serum C-peptide concentrations were significantly greater (p<0.05) in participants with Gleason scores 7(4+3) or higher (2.8 ± 1.1 ng/mL) compared to those with Gleason scores of 6(3+3) (1.4 ± 0.6 ng/mL) or Gleason 7(3+4) (1.3 ± 0.8 ng/mL). There were no significant differences in fasting glucose concentrations, but insulin and insulin resistance (HOMA-IR) tended to be greater in the group with Gleason scores of 7(4+3, p<0.01, suggesting greater insulin secretion, compared with those who had Gleason scores 6(3+3) and 7(3+4). Central adiposity measured by waist circumference, was significantly elevated (p<0.05) in those with the highest Gleason scores compared to those with lower Gleason scores (Gleason 7(4+3) or greater: 110.1±7.4 cm vs Gleason 7 (3+4): 102.0±9.5 cm). Men with the highest Gleason scores had significantly greater serum leptinlevels than those with lower Gleason scores (Gleason 7(4+3) or greater: 15604.4 ± 3290.5 pg/mL vs Gleason 7(3+4): 8131.5 ± 8069.7 pg/mL, p<0.05) and serum leptin:adiponectin ratio (Gleason 7(4+3) or greater: 2.4 ± 2.1 AU vs Gleason 7(3+4): 2.9 ± 3.2 AU, p<0.05). CONCLUSIONS This is the first study to integratively show that serum c-peptide, visceral adiposity, serum leptin and leptin to :adiponectin ratio are associated with high Gleason scores, suggesting a cluster of obesity related metabolic perturbations that may contribute to aggressiveness in prostate cancer. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e81 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Jehonathan H. Pinthus More articles by this author Katie M. Di Sebastiano More articles by this author Wilhelmina C.M. Duivenvoorden More articles by this author Joel A. Dubin More articles by this author Marina Mourtzakis More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...

Source: The Journal of Urology

DOI: 10.1016/j.juro.2016.02.2215

Authors: Jehonathan H. Pinthus, Katie M. Di Sebastiano, Wilhelmina C.M. Duivenvoorden, Joel A. Dubin, Marina Mourtzakis

Institution: Fonds de Recherche du Québec - Santé

Language: English

Topic: Prostate Cancer Diagnosis and Treatment

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2331577906

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