Dexmedetomidine premedication with three different dosages to attenuate the adverse hemodynamic responses of direct laryngoscopy and intubation: a comparative evaluation
Year: 2016
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: BackgroundDirect laryngoscopy and tracheal intubation predictably lead to transient and variable hemodynamic responses, which can be attenuated by α2-receptor agonists. The present study aimed to evaluate comparatively the three different dosages of dexmedetomidine (0.5, 0.8, and 1 μg/kg) as premedication for the attenuation of these hemodynamic responses of direct laryngoscopy and intubation.Participants and methodsNinety adult consented patients of ASA grades I and II of either sex were randomized into three equal groups of 30 patients each in a double-blind manner. Dexmedetomidine in dosages of 0.5 μg/kg (group I), 0.8 μg/kg (group II), and 1 μg/kg (group III) was infused over 10 min as premedication before propofol induction. The hemodynamic changes during infusion, after induction, and after laryngoscopy and intubation were recorded for statistical analysis.ResultsPatients with a comparable demographic profile showed a decrease in heart rate and blood pressure after dexmedetomidine infusion in a dose-dependent manner. Further decrease in heart rate and blood pressure after propofol induction showed a statistically significant (P < 0.05) difference among groups. After laryngoscopy and intubation, the increase in heart rate and blood pressure was more evident in patients in whom low dosages of dexmedetomidine was infused with a statistically significant (P < 0.05) difference among the groups.ConclusionPremedication with dexmedetomidine at a dosage of 1 μg/kg attenuated the adverse hemodynamic responses of laryngoscopy and intubation adequately.
Authors: Kumkum Gupta, Manoranjan Bansal, PrashantK Gupta, Meetu Singh, Shikha Agarwal, Vaibhav Tiwari
Language: English
Subfield: Anesthesiology and Pain Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2331680751