Work

Antitumor Polysaccharides from Some Polyporaceae, Ganoderma applanatum (PERS.) PAT and Phellinus linteus (BERK. et CURT) AOSHIMA

Year: 1971

Type: article

Abstract: Antitumor polysaccharide preparations G-Z and P-Z were fractionated from the water soluble extracts of Ganoderma applanatum (PERS.) PAT and Phellinus linteus (BERK. et CURT) AOSHIMA, basidiomycetes of Polyporaceae, respectively, by fractional precipitation with ethanol and cetyltrimethylammonium hydroxide. The structures of G-Z and P-Z consist of β-(1→3), (1→4) linked D-glucose residue, and β-(1→3) linked D-glucose residue, respectively. These polysaccharide preparations have marked antitumor activity against transplanted sarcoma 180 in mice, and a complete regression of tumors was observed in more than half of animals with no sign of toxicity. Some derivatives of P-Z were synthesized and their antitumor effects were also examined.

Source: Chemical and Pharmaceutical Bulletin

DOI: 10.1248/cpb.19.821

Authors: TAKUMA SASAKI, YOSHIKO ARAI, TETSURO IKEKAWA, GORO CHIHARA, FUMIKO FUKUOKA

Institution: National Cancer Center Research Institute

Language: English

Topic: Fungal Biology and Applications

Subfield: Pharmacology (medical)

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2331715664

FWCI:

Cites:

Cited by: 52

Related to: 10