1313 Clinical Significance of Preoperative Thrombocytosis in Patient Performed Radical Nephrectomy for Non-metastatic Renal Cell Carcinoma
Year: 2013
Type: article
Study design: Observational Study
Abstract: You have accessJournal of UrologyKidney Cancer: Localized (II)1 Apr 20131313 CLINICAL SIGNIFICANCE OF PREOPERATIVE THROMBOCYTOSIS IN PATIENT PERFORMED RADICAL NEPHRECTOMY FOR NON-METASTATIC RENAL CELL CARCINOMA Jae Seog Hyun, Phil Hyun Song, Yoon Seob Ji, Hong Seok Shin, Young Hwii Ko, Hee Chang Jung, and Ki Hak Moon Jae Seog HyunJae Seog Hyun Jinju, Korea, Republic of More articles by this author , Phil Hyun SongPhil Hyun Song Daegu, Korea, Republic of More articles by this author , Yoon Seob JiYoon Seob Ji Daegu, Korea, Republic of More articles by this author , Hong Seok ShinHong Seok Shin Daegu, Korea, Republic of More articles by this author , Young Hwii KoYoung Hwii Ko Daegu, Korea, Republic of More articles by this author , Hee Chang JungHee Chang Jung Daegu, Korea, Republic of More articles by this author , and Ki Hak MoonKi Hak Moon Daegu, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.02.2667AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The aim of this study was to investigate the association of preoperative thrombocytosis with the prognosis of patients with non-metastatic renal cell carcinoma (RCC). METHODS We performed a retrospective analysis of 187 patients who underwent a radical nephrectomy for non-metastatic RCC between July 1997 and June 2009. We defined thrombocytosis as a platetlet count ≥ 400,000/uL, and divided total patients into two groups according to presence of preoperative thrombocytosis, and compared the cancer-specific survival rates and overall survival rates of the two groups after radical nephrectomy. RESULTS The mean age of the total patients was 56.0±11.7 and the mean follow-up time was 59.3±42.1 months and there were 20 patients with preoperative thrombocytosis. Thirty patients developed metastases and nine patients died during the follow-up period. Kaplan-Meier analysis using a univariate log-rank test shows that both cancer-specific survival rate (p=0.013) and overall survival rate (p=0.012) were significantly associated with preoperative thrombocytosis. Controlling for pathological TNM stage, Fuhrman grade and tumor diameter, the Cox proportional hazards model for cancer-specific survival rates showed that preoperative thrombocytosis was an independent prognostic factor (p=0.042). CONCLUSIONS Preoperative thrombocytosis was associated with poorer prognosis in patients with non-metastatic RCC. Thus, preoperative platelet count may be clinically useful to stratify the risk in patients undergoing surgery for non-metastatic RCC. © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 189Issue 4SApril 2013Page: e536 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.MetricsAuthor Information Jae Seog Hyun Jinju, Korea, Republic of More articles by this author Phil Hyun Song Daegu, Korea, Republic of More articles by this author Yoon Seob Ji Daegu, Korea, Republic of More articles by this author Hong Seok Shin Daegu, Korea, Republic of More articles by this author Young Hwii Ko Daegu, Korea, Republic of More articles by this author Hee Chang Jung Daegu, Korea, Republic of More articles by this author Ki Hak Moon Daegu, Korea, Republic of More articles by this author Expand All Advertisement Advertisement Loading ...
Source: The Journal of Urology
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2331980239