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In vitro Effects of Glycyrrhizin on the Serum Enzymes in Chronic Hepatitis Patients

Year: 1980

Type: article

Abstract: In vitro effects of glycyrrhizin on the serum enzymes in chronic hepatitis patients were studied. Forty μg and 100 μg of glycyrrhizin per one ml of reaction mixture inhibited transaminase activity by about 10% and 32-37%, respectively, in a noncompetitive manner. The former concentration was comparable to the clinical dose by intravenous administration in the treatment of liver diseases. Glycyrrhizin also had inhibitory action on the activities of serum LDH and LAP, but not on MAO activity. Furthermore, this agent exhibited activation on acid RNase, but not on alkaline RNase.

Source: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics

DOI: 10.3999/jscpt.11.125

Authors: Kimihiro AKAGI, Koichiro MURAI, Tatsuru SHIKATA, Masayoshi YAMANAKA, Teruo OMAE

Institution: Kyushu University

Language: English

Topic: Pharmacological Effects of Natural Compounds

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2332698577

FWCI:

Cites: 10

Cited by: 1

Related to: 10