Work

A Subcutaneous Delta-Positive T-Cell Lymphoma That Produces Interferon Gamma

Year: 1991

Type: article

Abstract: WE report an unusual form of cutaneous T-cell lymphoma characterized by subcutaneous tumors that regress spontaneously, fever, progressive leukopenia, high levels of interferon gamma in the serum, and an increased natural-killer-cell activity of peripheral-blood mononuclear cells. Histologically, the infiltrate consists of nonepidermotropic, pleomorphic lymphoid cells located in the subcutaneous fatty tissue. These cells express the phenotype of immature (CD1+, CD3+, CD4-, CD5-, CD8-), activated (CD30+, CD25+, HLA-DR+) T cells positive for delta T-cell receptors. They express the natural-killer-cell phenotype (CD56+) and produce interferon gamma in cell culture. Case Report A 70-year-old woman presented in March 1985 with recurrent, spontaneously regressing, . . .

Source: New England Journal of Medicine

DOI: 10.1056/nejm199110103251506

Authors: Günter Burg, Reinhard Dummer, Martin Wilhelm, Frank Nestle, Maria Michaela Ott, Alfred Feller, Hiltrud Hefner, Ute Lanz, Andreas Schwinn, Johannes Wiede

Institutions: University of Würzburg, University Hospital Zurich, Universitätsklinikum Würzburg

Language: English

Topic: Cutaneous lymphoproliferative disorders research

Subfield: Dermatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2333059986

FWCI: 8.673

Cites: 20

Cited by: 161

Related to: 10