Year: 1980
Type: article
Abstract: The effect of spleen extract from irradiated rats on CFU-e and BFU-e colony formation of rat bone marrow cells was investigated by using modified plasma clot culture media. In the presence of erythropoietin (Ep), CFU-e colony formation peaked at 48 hr of culture, and the Ep-induced increase of CFU-e colonies was dose-dependent. The addition of spleen extract enhanced the colony formation more than two-fold in the Ep-containing culture. BFU-e colony formation was also enhanced by the addition of spleen extract. These results indicate that spleen extract from irradiated rats contains factor(s) which stimulates the proliferation of erythroid progenitors.
Authors: Shiro KASAI, Waka TERASAWA, Hiroaki KODAMA, Takashi TERASAWA
Language: English
Subfield: Hematology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2333201856