Year: 1995
Type: article
Study design: Case Report
Abstract: T HE use of colchicine is limited by its toxicity, 1 and colchicine overdose is associated with a high mortality rate.Patients with early hemodynamic collapse due to colchicine overdose have particularly poor prognoses, 2,3 and there has been no effective treatment for this complication of severe colchicine intoxication. 4olchicine binds reversibly to tubulin, 5 and colchicine-specific antibodies have been shown to restore the activity of tubulin in vitro. 6,7][10][11] These findings suggested that colchicine-specific Fab fragments could be of value in the treatment of life-threatening colchicine poisoning, such as is true of digoxin-specific Fab fragments in digitalis poisoning. 12e here describe the successful use of this treatment in a woman who had ingested 60 mg of colchicine in a suicide attempt.
Source: New England Journal of Medicine
Institutions: Hôpital Fernand-Widal, Inserm
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2339811333