Work

A Practical Synthesis of 4’-Fluorospiro[cyclopropane-1,3’-indol]-2’(1’H)-one: a Valuable Terminal Building-Block for Biologically Active Podands

Year: 2016

Type: article

Abstract: A practical one-pot synthesis of 4'-fluorospiro[cyclopropane-1,3'-indol]-2'(1'H)-one, including the treatment of 1-(2,6-difluorophenyl)cyclopropane-1-carbonitrile with potassium hydroxide in boiling glycol, as a key step, is described.The title product is recognized as a promising terminal building block for the novel biologically active podands.

Source: Macroheterocycles

DOI: 10.6060/mhc160110n

Authors: Alexandre S. Babushkin, Maxim B. Nawrozkij, Ivan A. Novakov, Alexandre S. Yablokov

Institutions: Volgograd State Technical University, Russian Academy of Sciences

Language: English

Topic: Fluorine in Organic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Russian Foundation for Basic Research

OpenAlex ID: W2339990474