Work

Long noncoding RNA expression profile analysis of colorectal cancer and metastatic lymph node based on microarray data

Year: 2016

Type: article

Abstract: Long noncoding RNAs (lncRNAs) are emerging as an important part of biological progress in cancers, yet the aberrant lncRNAs implicated in colorectal cancer (CRC) with lymph node metastasis remain unknown. In this study, a total of 390 lncRNA transcripts and 508 mRNA transcripts were dysregulated in tumor tissues compared with paired metastatic lymph nodes. Functional prediction showed that lots of lncRNAs might be involved in biological pathways related to CRC metastasis by cis-regulation and trans-regulation of coexpressed genes. As a representative, ENST00000430471 was associated with cell proliferation and invasion of CRC cells. These results provided support for further investigations of the metastatic pathogenesis of CRC.

Source: OncoTargets and Therapy

DOI: 10.2147/ott.s102348

Authors: Zhen-Yu He, Peng Yang, Zi-Peng Xu, Tao Chen

Institutions: Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University

Language: English

Topic: Cancer-related molecular mechanisms research

Subfield: Cancer Research

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,836