Meta-analysis of comparative study of duloxetine in the treatment of senile depression
Year: 2014
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Objective To study the difference of efficacy and side effect of duloxetine in the treatmrent of senile depression.Methods 10 comparative studies of duloxetine and other antidepressants in the treatment of senile depression were analyzed by meta-analysis. Results 1Self- comparison study of duloxetine before and after treatment showed that d = 4. 59,95% CI( 3. 01,6. 17),χ2=21. 5,P 0. 01. Comparison between duloxetine and the controlled antidepressants at 2 weeks treatment and at the end of each tril showed that Yco=- 0. 04,95% CI(- 0. 19,0. 11),χ2= 3. 86,P 0. 05,and Yco= 0. 01,95% CI(- 0. 14,0. 17),χ2= 3. 06,P 0. 05 respectiveiy,which revealed that there was no significant difference between duloxetine and the controlled antidepressants with respect to the clinical efficacy. There were no significant difference in side effect between these two groups. Conclusion Duloxetine is an safe and effective antidepressant in the treatment of senile depression.
Source: Sichuan Mental Health
Author: Wang Gang-pin
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W2358286264