Effect of metformin hydrochloride on serum uric acid in type 2 diabetes mellitus patients
Year: 2010
Type: article
Abstract: Objective:To investigate the effect of metformin hydrochloride on serum uric acid in type 2 diabetes mellitus patients,and its influencing factors.Methods:Using a self-control method,the serum uric acid levels were observed in 480 cases of type 2 diabetes mellitus patients who long-term use of metformin hydrochloride at the periods of selected,wash off and the resumption of metformin conventional treatment.The effect of other biochemical indicators including age,duration,blood pressure,body mass index,and metformin daily dose on clinical factors such as serum uric acid change was also observed.Results:Serum uric acid levels of the patients in three periods were(376±90)μmol/L,(355±88)μmol/L,(391±80)μmol/L,and the uric acid was significantly higher in selection and resumption periods than that in washed periodP﹤0.05,respectively).As a whole in the 480 cases,the uric acid changes during wash off and resumption of metformin conventional treatment was as the dependent variable Y(higher =1;no increase=0),age,diabetes history,systolic blood pressure,diastolic blood pressure,body mass index,fasting blood glucose,alanine aminotransferase(ALT),serum creatinine,serum uric acid and metformin daily dose were as independent variables(X1-X10)respectively,Logistic step regression analysis was carried out.Variables selections are age,baseline serum uric acid level and metformin daily dose.Conclusion:Serum uric acid level is elevated mildly in type 2 diabetes mellitus patients taking metformin hydrochloride.Elevated level of serum uric acid is relevant to eld,high baseline level of serum uric acid and higher dose of metformin daily.
Source: New Medicine
Author: FU Xiaoying
Institution: Guangdong Provincial People's Hospital
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $46
OpenAlex ID: W2363595288