Work

Effect of Amlodipine, Cilnidipine and Diltiazem on lipid profiles of hypertensive rats fed with high fat diet: A comparative study

Year: 2016

Type: article

Abstract: Objective The present study was aimed to compare the effect of calcium channel blocker (Amlodipine, Cilnidipine and Diltiazem) on lipid profiles of hypertensive rats fed with high fat diet for four weeks. Methods Hypertensive rats were randomly allocated into four groups and except hypertensive rats remaining all groups received high fat diet for 4 weeks. At the end of protocol blood pressure was measured by tail cuff method and blood is withdrawn from the retro-orbital puncture, separated serum is used for the assessment of various biochemical parameters. Finally liver and aorta isolated for histological changes. Results Calcium channel blocker significantly reduces the lipid levels raised in hypertensive rats fed with high fat diet and also restore the pathological changes of aorta and liver tissues. Conclusion These results indicate that they have a lipid lowering effect due to effect on different stages of metabolism of lipids.

Source: Bulletin of Faculty of Pharmacy Cairo University

DOI: 10.1016/j.bfopcu.2016.04.001

Authors: Nim Bahadur Dangi, Akkiraju Sudheer, S.P. Rathod, Hari Prasad Sapkota

Institution: Maharaja Sayajirao University of Baroda

Language: English

Topic: Blood Pressure and Hypertension Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: All India Council for Technical Education