Association between Diabetes Mellitus and Hepatocellular Carcinoma:A Meta-analysis of Cohort Study
Year: 2010
Type: review
Study designs: Systematic Review, Meta-Analysis
Abstract: Objective To explore the hypothesis that diabetes mellitus (DM) may cause hepatocellular carcinoma (HCC),by evaluating the association between DM and HCC by means of meta-analysis.Methods Cochrane Library,Medline,PubMed,EMBASE,OVID and CBMdisc databases were searched,and a manual search of citations from relevant original studies and literature also was performed. The data were pooled using RevMan 4.3 software for meta-analysis,and the potential bias was assessed by sensitivity analysis,funnel plot and fail-safe number.Results A total of 15 cohort studies were included,and 6 studies (the outcome of HCC was occurrence) were analyzed. DM was associated significantly with the occurrence of HCC (pooled RR=2.37,95%CI:1.76~3.21). Sensitivity analysis showed the results of meta-analysis were insusceptible,publication bias was found in the studies,but it's effect was too limited to be ignored.Conclusion A significant causal association between DM and HCC was observed,it suggests that DM may be a risk factor of HCC.
Source: Zhongliu fangzhi yanjiu
Institution: Guilin Medical University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2392531270