Work

Inhibition of PKCε induces primordial germ cell reprogramming into pluripotency by HIF1&2 upregulation and histone acetylation.

Year: 2015

Type: article

Abstract: OBJECTIVE: To report bone marrow derived stem cell application in a patient with bilateral visual loss due to accidental ingestion of methanol. METHOD: A 22-year-old male patient with bilateral visual loss at discharge after treatment for methanol ingestion was treated with retrobulbar and intrathecal autologus bone marrow derived stem cells in an outpatient setting. The procedure was followed by Vit B12 Injection 500 mcg alternate days and oral vitamins B1, B2, B6, in therapeutic dose for 3 months. RESULT: The patient demonstrated favorable outcome three days after the treatment. Visual acuity improved to 20/20 in both eyes by third week. CONCLUSION: Treatment with retrobulbar and intrathecal autologous bone marrow derived stem cell in an adult male patient with bilateral visual loss due to accidental ingestion of methanol was effective. Larger studies are warranted to explore the real impact of this procedure.

Source: PubMed

Authors: Adrian Moratilla, Diego Sainz de la Maza, Marta Cadenas Martin, Pilar López-Iglesias, Pilar González-Peramato, Maria P De Miguel

Institutions: Hospital Universitario La Paz, Hospital La Paz Institute for Health Research

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2396561148

FWCI: 0.115

Cites: 59

Cited by: 8

Related to: 10