Examination of Particulate Contamination after Opening Ampoules-Relationship between Ampoule Inner-diameter and Glass Particle Accumulation after Opening Ampoules-
Year: 2008
Type: article
Abstract: The purpose of this study was to clarify the relationship between the inner-diameter of an ampoule and the amount of glass particle accumulation after opening ampoules.All of the ampoules used in the study were snapped open by hand and left to stand undisturbed for 120 seconds.Tilting the ampoules,the solutions in them were aspirated using an 18 G nonfiltered needle attached to a 5 mL syringe.The contents of the ampoules were then diluted with 0.6-4 mL distilled water and passed through a 0.20 mm membrane filter.Amounts of remaining particles were measured using a KL-04 particle counter after aspiration of the ampoule contents.Our results suggested that glass particulate contamination was positively correlated with the inner-diameter of the ampoule,but not with the thickness of the ampoule walls.This finding could help prevent the injection of glass particles into patients,and the use of filters may further decrease the risk of this happening.
Authors: Yoichi Kawasaki, Naoyuki Matsuka, Takeo Okada, Rieko Kawashima, Noriko Kitagawa, Toshiaki Sendo, Yutaka Gomita
Institutions: Okayama University Hospital, Shujitsu University
Language: English
Subfield: Analytical Chemistry
Field: Chemistry
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2396692467