Year: 2005
Type: article
Study design: Observational Study
Abstract: Background : Idiopathic membranoproliferative glomerulonephritis (MPGN) is a chronic\nprimary glomerular disease that occurs in both children and adults, with generally progressive\ncourse. We have examined the clinical and long-term outcome of patients with idiopathic\nMPGN at Keimyung University Dongsan Medical Center.\nMethods : Of the total 1,971 patients with biopsy-proven glomerulonephritis over the\n21-year period from June 1982 and June 2003, there were 51 cases of idiopathic MPGN of\nwhom 49 had type Ⅰ and two type Ⅱ.\nResults : Of the total 51 idiopathic MPGN, male to female ratio was 1.7:1, a mean age at\ndiagnosis was 32±17 years (range; 6-70) and 50% of the patients were under the age of 30.\nThe clinical presentations at the time of diagnosis were nephrotic syndrome (70%), asymptomatic\nurinary abnormality (18%), acute nephritic syndrome (6%), and recurrent gross\nhematuria (6%). Of the 40 patients who followed more than 6 months, with a mean\nfollow-up of 71months, 10 patients progressed to end-stage renal disease. The renal survival\nat 5 and 10 years after diagnosis were 86 and 52%, respectively. Eight (20%) patients\nobtained a complete remission and none of them progressed to end-stage renal failure. The\nquantity of proteinuria at the time of biopsy was much more prominent in deteriorating\ngroup, though not significant (p=0.05) and young age and female seemed associated with the\ncomplete remission (p<0.05).\nConclusion : Idiopathic MPGN remains a disease with a poor prognosis. Age, gender and\nquantity of proteinuria at the time of diagnosis were associated with the prognosis. Further\nprospective study with larger number of patients would be necessary to assess the prognostic\nfactors and effective therapy for idiopathic MPGN.(Korean J Med 68:195-202, 2005)\nKey Words : Idiopathic MPGN, Epidemiology, Long-term outcome
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2397629931