Work

Interaction of Testosterone and Testosterone Receptor Complexes with Nuclei of Skeletal Muscle from Intact Male Mice and from Mice Bearing the Testicular Feminization (Tfm) Mutant Gene

Year: 1988

Type: article

Abstract: With the nuclear exchange assay and the nuclear retention assay it is shown that the androgen insensitivity of Tfm mice is probably due to a defect of the nuclear acceptor sites for the testosterone receptor complex. Further on the results obtained point strongly to the possibility that hormone free androgen receptor is localized in the nuclei and in the cytoplasma according to the "equilibrium model". A practicable method for separation of unbound steroids from nuclei is described.

Source: Zeitschrift für Naturforschung C

DOI: 10.1515/znc-1988-3-415

Authors: Cornelia Franzelius, Karl Eisele

Institution: University of Tübingen

Language: English

Topic: Hormonal and reproductive studies

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

Open Access status: hybrid

Estimated APC paid: $2,712

Funder: Deutsche Forschungsgemeinschaft