Year: 2016
Type: article
Abstract: Capsid protein of norovirus genogroup II (GII) plays crucial roles in host infection. Although studies on capsid gene evolution have been conducted for a few genotypes of norovirus, the molecular evolution of norovirus GII is not well understood. Here we report the molecular evolution of all GII genotypes, using various bioinformatics techniques. The time-scaled phylogenetic tree showed that the present GII strains diverged from GIV around 1630CE at a high evolutionary rate (around 10(-3) substitutions/site/year), resulting in three lineages. The GII capsid gene had large pairwise distances (maximum > 0.39). The effective population sizes of the present GII strains were large (>10(2)) for about 400 years. Positive (20) and negative (over 450) selection sites were estimated. Moreover, some linear and conformational B-cell epitopes were found in the deduced GII capsid protein. These results suggested that norovirus GII strains rapidly evolved with high divergence and adaptation to humans.
Source: Scientific Reports
DOI: 10.1038/srep29400
Authors: Miho Kobayashi, Yuki Matsushima, Takumi Motoya, Naomi Sakon, Naoki Shigemoto, Reiko Okamoto-Nakagawa, Koichi Nishimura, Yasutaka Yamashita, Makoto Kuroda, Nobuhiro Saruki, Akihide Ryo, Takeshi Saraya, Yukio Morita, Komei Shirabe, Mariko Ishikawa, Tomoko Takahashi, Hiroto Shinomiya, Nobuhiko Okabe, Koo Nagasawa, Yoshiyuki Suzuki, Kazuhiko Katayama, Hirokazu Kimura
Institutions: Gunma Prefectural Institute of Public Health and Environmental Sciences, Kawasaki City Institute for Public Health, Ibaraki Prefectural Institute of Public Health, Osaka Prefectural Institute of Public Health, Hiroshima Prefectural Technology Research Institute, Public Health and Environment Center, Yamaguchi Prefectural Institute of Public Health and Environment, Kumamoto Prefectural Institute of Public-Health and Environmental Science, Ehime Prefectural Institute of Public Health and Environmental Science, National Institute of Infectious Diseases, Yokohama City University, Kyorin University, Tokyo Kasei University, Nagoya City University
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
OpenAlex ID: W2400549233