Effect of chrysin on nociception in formalin test and serum levels of noradrenalin and corticosterone in rats.
Year: 2015
Type: article
Abstract: OBJECTIVE: The levels of corticosterone and noradrenalin as the two nociception modulators modify after stress condition. The propose of current study was to investigate the effect of chrysin on formalin-induced nociceptive behaviors and serum levels of corticosterone and noradrenalin in rats. MATERIALS AND METHODS: Pain was induced by applying 20 μL of 5% formalin in distilled water in the subplantar of the right hind paw. Chrysin (50, 100 and 150 mg/kg, intraperitoneally (i.p.) was administered 60 min before formalin injection. Morphine (10 mg/kg, i.p.) was administered 30 min before formalin injection. The control group received the same volume of saline by i.p. injection 30 min before formalin injection. RESULTS: Chrysin treatment can significantly decrease formalin-induced pain in rat in a dose-dependent manner. Chrysin (150 mg/kg) significantly inhibit the first phase (P < 0.01), whereas, the all concentration of chrysin were affected on the later phase of formalin-induced pain (P < 0.05). Chrysin could significantly attenuate the content of corticosterone and noradrenalin in the serum versus to the control rats (P < 0.01). CONCLUSION: The current study confirms that the chrysin decreased the nociceptive behaviors in the formalin test and indicate a correlation with decrease in serum corticosterone and noradrenalin levels.
Source: PubMed
Language: English
Subfield: Physiology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2401697607