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Synthesis and Antiinflammatory Activity of Hydrocortisone 17, 21-Diesters

Year: 1982

Type: article

Abstract: A new series of hydrocortisone 17, 21-diesters was prepared and their antiinflammatory activity was evaluated by the croton oil ear edema inhibition test in rats. The most potent compound was hydrocortisone 17-butyrate 21-propionate which was more active than betamethasone 17-valerate.

Source: YAKUGAKU ZASSHI

DOI: 10.1248/yakushi1947.102.4_365

Authors: KAORU SOTA, MORIHIRO MITSUKUCHI, JOZI NAKAGAMI, YASUHIDE TACHI, JIRO SAWADA, SUSUMU OTOMO, MASAHIRO OHZEKI

Language: Japanese

Topic: Heterocyclic Compound Synthesis and Bioactivity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2402857166

FWCI: 0.562

Cites:

Cited by: 5

Related to: 10