Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1
Year: 2015
Type: article
Abstract: Five new compounds, pinazaphilones A and B (1, 2), two phenolic compounds (4, 5), and penicidone D (6), together with the known Sch 1385568 (3), (±)-penifupyrone (7), 3-O-methylfunicone (8), 5-methylbenzene-1,3-diol (9), and 2,4-dihydroxy-6-methylbenzoic acid (10) were obtained from the culture of the endophytic fungus Penicillium sp. HN29-3B1, which was isolated from a fresh branch of the mangrove plant Cerbera manghas collected from the South China Sea. Their structures were determined by analysis of 1D and 2D NMR and mass spectroscopic data. Structures of compounds 4 and 7 were further confirmed by a single-crystal X-ray diffraction experiment using Cu Kα radiation. The absolute configurations of compounds 1-3 were assigned by quantum chemical calculations of the electronic circular dichroic spectra. Compounds 2, 3, 5, and 7 inhibited α-glucosidase with IC50 values of 28.0, 16.6, 2.2, and 14.4 μM, respectively, and are thus more potent than the positive control, acarbose.
Source: Journal of Natural Products
DOI: 10.1021/np500885f
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Energy, U.S. Department of the Interior, University of Connecticut, Villum Fonden, Innovationsfonden, European Cooperation in Science and Technology, Agence Nationale de la Recherche, National Natural Science Foundation of China, Ministry of Education of the People's Republic of China, Ministerio de Economía y Competitividad, National Research Foundation of Korea, Ministry of Land and Resources of the People's Republic of China, U.S. Geological Survey, Dalian Institute of Chemical Physics, Program for New Century Excellent Talents in University, State Oceanic Administration, Seventh Framework Programme, National Key Research and Development Program of China, Fundamental Research Funds for the Central Universities, National Cancer Institute, National Institute of General Medical Sciences, Division of Materials Research, Division of Chemistry
Awards: 我国环境汞污染的来源、化学特征及转化机制研究, G1164086413, G1241154327, G1753823200, G1775130492, G2117199515, G2404457243, G2452932268, G2552434159, G2599963932, G3238051054, G3838742685, G4192179106, G4208223831, 级联信号放大疾病标志物高灵敏、多组分同时电化学生物传感研究, G4801379320, G4869852581, HEMISPHERE CENTER FOR ENVIRONMENTAL TECHNOLOGY, G5046954591, G5611930393, G5877631857, G6198720419, Enantioselective Catalysis with Cyclopropenimines, Synchrotron Radiaton for Tandem Mass Spectrometry, G7034621906, G7261981869, G7262419837, G7503906131, 南海红树秋茄内生真菌多样性及抗肿瘤活性代谢产物研究, G7818954563, 酶催化原位生成共反应试剂增强电致化学发光的超灵敏适体传感器研究, G858682239, G8731706598, Brook重排介导的连续反应构筑beta-氨基-alpha-季碳羟基酯及其在天然产物合成中的应用研究, G8863922270, G998081132
OpenAlex ID: W2408994368